Conversion of Yohimbine into beta-Yohimbine and 3-epi-beta-Yohimbine.
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چکیده
منابع مشابه
Yohimbine in the treatment of orgasmic dysfunction.
AIM To study the effect of yohimbine in the treatment of men with orgasmic dysfunction. METHODS A 20-mg dose of yohimbine was first given to 29 men with orgasmic dysfunction of different aetiology in the clinic. Patients were then allowed to increase the dose at home (titration) under more favourable circumstances. The outcome and side effects were subsequently assessed. RESULTS The patient...
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Alpha-2 adrenoreceptor stimulation profoundly augments baroreflex-mediated bradycardia presumably through parasympathetic activation. We tested the hypothesis that endogenous alpha-2 adrenergic tone mediates a similar response. In 10 healthy men (age: 33+/-3 years; body mass index: 24+/-1.3 kg/m(2)), we determined baroreflex control of heart rate and sympathetic traffic after ingestion of the s...
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In this study, we evaluated if increased sympathetic stimulation is an essential requirement for the development of neurally mediated syncope (NMS) by manipulating overall sympathetic outflow in subjects susceptible to tilt-induced syncope. Eight previously characterized patients with recurrent NMS (five females and three males; 34+/-2 yr) were recruited from the Vanderbilt Syncope Unit and eig...
متن کاملYohimbine Dimers Exhibiting Selectivity for the Human 2c-Adrenoceptor Subtype
Yohimbine is a potent and selective 2versus 1-adrenoceptor antagonist. To date, drugs with high specificity for the 2-adrenoceptor show marginal selectivity among the three 2-adrenoceptor subtypes. Initial studies showed that yohimbine was about 4and 15-fold more selective for the human 2C-adrenoceptor in comparison with the 2Aand 2B-adrenoceptors, respectively. To improve on this 2-adrenocepto...
متن کاملCase study: two fatal case reports of acute yohimbine intoxication.
Yohimbine is an alkaloid that has been encountered on the streets as an aphrodisiac, hallucinogen, dietary supplement and erectile dysfunction drug. Yohimbine hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine. An average oral dose of 5-15 mg produces a therapeutic whole...
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ژورنال
عنوان ژورنال: Acta Chemica Scandinavica
سال: 1957
ISSN: 0904-213X
DOI: 10.3891/acta.chem.scand.11-1013